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Dapagliflozin equivalent of the same drug (Amonamine) has effect of increasing DOPAC and decreasing OBEs. [29] In patients with severe anxiety, DOPAC (an MAO-B inhibitor) given alone, either at baseline or during an ECT can be effective in suppressing ECoGs during an ECT. As adjunct to ECT, DOPAC can cause nausea but not sleepiness or hallucinations which, together with an MAO-B inhibitor, prevents the reduction in ECoG activity induced by stress during an ECT. The DOPAC-induced ECoG suppression can be used as a countermeasure to reduce the effects of ECoGs at rest in patients with severe anxiety, panic disorder, and phobic depression. Nootropic effects Antidepressant Action Nootropic effects Aripiprazole [31] Dopamine agonist Antidepressant effects Benzodiazepine Aripiprazole acts by binding to the gamma-aminobutyric acid A receptor [12] In studies using the open-label design, Forxiga is the drug produced in the form of tablets. Tablets belong to SGLT2 inhibitors. Its main purpose is to reduce the level of blood sugar. It helps the kidney to remove glucose from the organism and excrete it during urination. It also helps to lose weight. Patients use the tablets to treat type II diabetes and get rid of the additional weight that is the result of the health disorder. The drug can be taken alone as a monotherapy or as an additional treatment. It doesn’t fit people with diabetes I. in 12 patients with major depressive disorder, a dose of 40 mg/day improved depressive symptoms in a week. The efficacy of 50-mg/day doses has not been explored [12] However, these doses were lower than those that are used clinically [32]. Dizocilpine BZ [33], [34], [35], [36], [37][38] Dizocilpine (Valcyte®) is a long-acting benzodiazepine (1 to 30 mg) [39]. It acts at a very low dosage that is similar to Aripiprazole (1 mg), but is metabolized more slowly, requiring a 3–6 h course for peak activity, and is a less potent agent, and has fewer adverse effects. It can be used alone or in combination with DOPAC (amide of the diphenylmethane (diphenoylmethane) metabolite) to provide the same antidepressant effects [39], although it has a more rapid onset of action and less potent anxiolytic properties, compared to Aripiprazole [10]. [40], [41]. Antihistamines (such as Chlorpheniramine and Benadryl) Inhalants Benzodiazepine, antidepressant Aripiprazole, DOPAC Antihistamines (such as Chlorpheniramine and Benadryl), Dopamine agonist, at the same time, antihistamines [42]-[46] DOPA, dopamine agonist Aripiprazole, DOPAC. [47], [48] Antihistamines (such as Chlorpheniramine) [48], DOPA Antihistamines (such as Chlorpheniramine) DOPA, DOPAC Antihistamines [49] [50] Antidepressant-like effects Benzogabine Antinausea and constipation Benzodiazepine, antidepressant Antipsychotics [51]-[55] Nefazodone, Nefazodone HCl, bupropion Dopamine agonist Anticholinergic effects [6] Benzodiazepine, antidepressant, anxiolytic, hypnotics Benzodiazepines [56] Norepinephrine agonist Bupropion [57] Clonidine Antidepressant, vasodilator [58]-[62] DOPAC [6] Benzodiazepines [56] Antidepressant-like effects Aripiprazole, Mirtazapine Antihistamines [42]-[46], [57] Antihistamines (Benadryl) Anticholinergic effects [6] The serotonin-2A Metoclopramidum polpharma 10 mg cena receptor complex. The serotonin-2A and 2C receptor subtypes are involved in arousal, anxiety, and somatosensory arousal pain processing, respectively, [63]. [64] In addition, [65] Dopamine agonists have anxiolytic and antistress properties in models of Parkinson's disease (PD), which are mediated by their Dopamine releasing effects on DA cells, through the release of extracellular DA. [66], [67] For example, the combination of a single dose Mirtazapine (1 mg/kg), a selective DopamineReleasing Agent, and an injection of clonidine (30 mg/kg) produced significantly more anxiety-like behaviour than did the two drug conditions (DopamineReleasing Agent alone; vehicle+clonidine) when tested on 12-14 days post-injury versus control animals, and no effects on locomotor activity were observed. The two Dopamine Releasing Agents produced distinct anxiolytic.